Medical Researches
Possibly Effective
Based on 37 Researches
We studied the effects of BD400 in a collagen-induced arthritis rat model, aiming to understand if it could delay rheumatoid arthritis (RA). Through monitoring arthritis signs, measuring gut health, and assessing immune responses, we found that BD400 significantly reduced swelling and clinical scores in the rats.
Additionally, it positively impacted the gut microbiota and metabolite levels, particularly through histidine metabolism. This led to a decrease in inflammation and improved intestinal barrier function, hinting at BD400's potential as a preventive treatment for RA.
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We examined how a special probiotic mix, known as IRT5, affects autoimmune diabetes in non-obese diabetic (NOD) mice. Administered frequently over 36 weeks, this combination not only reduced diabetes incidence but also lowered insulitis scores and increased insulin-producing β-cell mass.
Additionally, IRT5 improved gut health and changed the makeup of immune cells in the pancreas and intestines. While some immune responses stayed the same, the shift towards more gut-focused regulatory T cells suggests it could be a promising treatment for type 1 diabetes.
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Synbiotics improve rheumatoid arthritis symptomsSynbiotic supplementation and the effects on clinical and metabolic responses in patients with rheumatoid arthritis: a randomised, double-blind, placebo-controlled trial.
High relevance; significant findings
We investigated how synbiotic supplementation affects patients with rheumatoid arthritis (RA). In an 8-week, randomized, double-blind trial involving 54 participants, we compared the outcomes of those taking synbiotic capsules with a placebo group.
After the trial, those who received synbiotics showed a significant drop in inflammation markers and pain levels. Additionally, improvements were observed in insulin resistance and overall metabolic responses.
These findings suggest that synbiotics might benefit individuals managing RA by reducing inflammation and enhancing metabolic health.
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We explored how specific Lactobacillus acidophilus strains can impact autoimmune disorders by reducing leptin production in mice. In our study, we compared the effects of CBA4P and other lactobacilli on adipocytes from mice sensitive to Th1 immune diseases.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
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We examined how probiotics, specifically Lactobacillus rhamnosus, could help with rheumatoid arthritis (RA) symptoms. By isolating monocytes from RA patients and healthy individuals, we created macrophages and tested various treatments.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
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User Reviews
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Previously struggling with autoimmune disorder, I noticed significant improvements in my bowel movements after taking this product. I hope it is effective for my vaginitis, the original aim of my intake.
This probiotic has effectively eliminated my thrush temporarily; however, my main aim was to improve my gastrointestinal tract. It seems to be a good supplement for normalising microflora, and I believe it may combat thrush effectively.